Lentiviral vector expression of tumour antigens in dendritic cells as an immunotherapeutic strategy

Abstract

Therapeutic cancer vaccines need to stimulate a refractory immune system to make an effective anti-tumour response. We have explored the use of lentiviral vectors to deliver tumour antigen genes to dendritic cells (DC) as a possible mechanism of immune stimulation. Direct injection of a lentiviral vector encoding the melanoma antigen NY-ESO-1 in HLA-A2… (More)
DOI: 10.1007/s00262-005-0095-5

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