Lentiviral vector design using alternative RNA export elements

  title={Lentiviral vector design using alternative RNA export elements},
  author={Tae Keun Oh and Ali I. Bajwa and Guangfu Jia and Frank Park},
  pages={38 - 38}
Lentiviral vectors have been designed with complex RNA export sequences in both the integrating and packaging plasmids in order to co-ordinate efficient vector production. Recent studies have attempted to replace the existing complex rev/RRE system with a more simplistic RNA export system from simple retroviruses to make these vectors in a rev-independent manner. Towards this end, lentiviral transfer plasmids were modified with various cis-acting DNA elements that co-ordinate RNA export during… CONTINUE READING
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