Lentiviral vector design for optimal T cell receptor gene expression in the transduction of peripheral blood lymphocytes and tumor-infiltrating lymphocytes.

@article{Jones2009LentiviralVD,
  title={Lentiviral vector design for optimal T cell receptor gene expression in the transduction of peripheral blood lymphocytes and tumor-infiltrating lymphocytes.},
  author={Stephanie M. Jones and Peter D. Peng and Shicheng Yang and Cary Hsu and Cyrille J. Cohen and Yangbing Zhao and John D Abad and Zhili Zheng and Steven A Rosenberg and Richard A. Morgan},
  journal={Human gene therapy},
  year={2009},
  volume={20 6},
  pages={630-40}
}
Lentiviral vectors containing promoters of distinct origins, that is, strong viral promoters (cytomegalovirus [CMV] and murine stem cell virus [MSCV]), a cellular promoter (phosphoglycerate kinase [PGK]), and two composite promoters (CAG [a composite promoter sequence comprised of the CMV enhancer and portions of the chicken beta-actin promoter and the rabbit beta-globin gene] and SV40/CD43), were used to evaluate green fluorescent protein (GFP) reporter gene expression in human primary… CONTINUE READING

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Lentivirusmediated gene transfer and expression in established human tumor antigen-specific cytotoxic T cells and primary unstimulated T cells

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