Lentiviral vector-based prime/boost vaccination against AIDS: pilot study shows protection against Simian immunodeficiency virus SIVmac251 challenge in macaques.

@article{Beignon2009LentiviralVP,
  title={Lentiviral vector-based prime/boost vaccination against AIDS: pilot study shows protection against Simian immunodeficiency virus SIVmac251 challenge in macaques.},
  author={Anne-Sophie Beignon and Karine Mollier and Christelle Liard and Fr{\'e}d{\'e}ric Coutant and Sandie Munier and Julie Rivi{\`e}re and Philippe Souque and Pierre Charneau},
  journal={Journal of virology},
  year={2009},
  volume={83 21},
  pages={10963-74}
}
AIDS vaccination has a pressing need for more potent vaccination vectors capable of eliciting strong, diversified, and long-lasting cellular immune responses against human immunodeficiency virus (HIV). Lentiviral vectors have demonstrated efficiency not only as gene delivery vehicles for gene therapy applications but also as vaccination tools. This is likely due to their ability to transduce nondividing cells, including dendritic cells, enabling sustained endogenous antigen presentation and… CONTINUE READING

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HIV VECTORS AS HIV VACCINE 10973 on A ril 13

  • J. Liu, K. L. O’Brien, +4 authors VOL
  • Nature
  • 2009
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