Lentiviral-mediated targeted transgene expression in dorsal spinal cord glia: tool for the study of glial cell implication in mechanisms underlying chronic pain development.

@article{Meunier2008LentiviralmediatedTT,
  title={Lentiviral-mediated targeted transgene expression in dorsal spinal cord glia: tool for the study of glial cell implication in mechanisms underlying chronic pain development.},
  author={Alice Meunier and Annie Mauborgne and Justine Masson and Jacques Mallet and Michel Pohl},
  journal={Journal of neuroscience methods},
  year={2008},
  volume={167 2},
  pages={148-59}
}
Activated glial cells in the dorsal spinal cord take an important part in the development of pain after peripheral nerve injury. Our understanding of mechanisms involved in functional changes of spinal glia remains incomplete. Excepting drugs that completely disrupt glial function, pharmacological studies fail to target glia and to modify locally its function in order to really discriminate the role of neuronal versus glial cells in chronic pain. We developed an intraspinal gene transfer… CONTINUE READING