Lentiviral-mediated RNA interference.

  title={Lentiviral-mediated RNA interference.},
  author={Toufik Abbas-Terki and William Blanco-Bose and Nicole D{\'e}glon and William François Pralong and P. Aebischer},
  journal={Human gene therapy},
  volume={13 18},
RNA interference (RNAi) is a form of posttranscriptional gene silencing mediated by short double-stranded RNA, known as small interfering RNA (siRNA). These siRNAs are capable of binding to a specific mRNA sequence and causing its degradation. The recent demonstration of a plasmid vector that directs siRNA synthesis in mammalian cells prompted us to examine the ability of lentiviral vectors to encode siRNA as a means of providing long-term gene silencing in mammalian cells. The RNA-polymerase… CONTINUE READING


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