Lentiviral-mediated GATA-3 RNAi decreases allergic airway inflammation and hyperresponsiveness.

  title={Lentiviral-mediated GATA-3 RNAi decreases allergic airway inflammation and hyperresponsiveness.},
  author={C N Lee and Hsin-Ying Huang and Bor-Luen Chiang},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  volume={16 1},
GATA-3 is the key transcriptional factor for Th2 commitment in T cells and is strongly associated with asthma and allergic disease. We studied the silencing of the GATA-3 gene expression using RNA interference (RNAi) delivered by a lentiviral vector, to evaluate the therapeutic role of GATA-3 short hairpin RNAs (shRNAs) in a murine model of asthma. Mice were sensitized with OVA and instilled intratracheally (IT) with GATA-3 shRNAs lentiviral vector (Lenti-si-GATA-3) once, 48 hours before… CONTINUE READING


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