Lentiviral delivery of RNAi for in vivo lineage-specific modulation of gene expression in mouse lung macrophages.


Although RNA interference (RNAi) has become a ubiquitous laboratory tool since its discovery 12 years ago, in vivo delivery to selected cell types remains a major technical challenge. Here, we report the use of lentiviral vectors for long-term in vivo delivery of RNAi selectively to resident alveolar macrophages (AMs), key immune effector cells in the lung… (More)
DOI: 10.1038/mt.2013.19


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