Lentiviral Vectors as a Gene Delivery System in the Mouse Midbrain: Cellular and Behavioral Improvements in a 6-OHDA Model of Parkinson's Disease Using GDNF

@article{Bensadoun2000LentiviralVA,
  title={Lentiviral Vectors as a Gene Delivery System in the Mouse Midbrain: Cellular and Behavioral Improvements in a 6-OHDA Model of Parkinson's Disease Using GDNF},
  author={Jean-Charles Bensadoun and Nicole D{\'e}glon and Jack L. Tseng and Jean-Luc Ridet and P. Aebischer},
  journal={Experimental Neurology},
  year={2000},
  volume={164},
  pages={15-24}
}
Local delivery of therapeutic molecules represents one of the limiting factors for the treatment of neurodegenerative disorders. In vivo gene transfer using viral vectors constitutes a powerful strategy to overcome this limitation. The aim of the present study was to validate the lentiviral vector as a gene delivery system in the mouse midbrain in the perspective of screening biotherapeutic molecules in mouse models of Parkinson's disease. A preliminary study with a LacZ-encoding vector… CONTINUE READING
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