Lentiviral Vector Delivery of Human Interleukin-7 (hIL-7) to Human Immune System (HIS) Mice Expands T Lymphocyte Populations

@inproceedings{Oconnell2010LentiviralVD,
  title={Lentiviral Vector Delivery of Human Interleukin-7 (hIL-7) to Human Immune System (HIS) Mice Expands T Lymphocyte Populations},
  author={Ryan M O'connell and Alejandro B. Balazs and D. Satyavardhana Rao and Christine Kivork and Lili Yang and David Baltimore},
  booktitle={PloS one},
  year={2010}
}
Genetically modified mice carrying engrafted human tissues provide useful models to study human cell biology in physiologically relevant contexts. However, there remain several obstacles limiting the compatibility of human cells within their mouse hosts. Among these is inadequate cross-reactvitiy between certain mouse cytokines and human cellular receptors, depriving the graft of important survival and growth signals. To circumvent this problem, we utilized a lentivirus-based delivery system to… CONTINUE READING

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