Lentiviral-RNA-interference system mediating homogenous and monitored level of gene silencing in human embryonic stem cells.

Abstract

Genetic modifications of human embryonic stem cells (hESCs) that will efficiently promote stable homogenous gene silencing, and will also allow monitoring of the silencing level, may be invaluable for the study of function of genes in early human embryogenesis, differentiation, and maintenance of pluripotency of hESCs. RNA-mediated interference (RNAi… (More)

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