Lens-specific expression of transforming growth factor beta1 in transgenic mice causes anterior subcapsular cataracts.

@article{Srinivasan1998LensspecificEO,
  title={Lens-specific expression of transforming growth factor beta1 in transgenic mice causes anterior subcapsular cataracts.},
  author={Yogambal Srinivasan and Frank J. Lovicu and Paul Overbeek},
  journal={The Journal of clinical investigation},
  year={1998},
  volume={101 3},
  pages={
          625-34
        }
}
Transgenic mice were generated by microinjection of a construct containing a self-activating human TGF-beta1 cDNA driven by the lens-specific alphaA-crystallin promoter. Seven transgenic founder mice were generated, and four transgenic lines expressing TGF-beta1 were characterized. By postnatal day 21, mice from the four families exhibited anterior subcapsular cataracts. The lenses in these mice developed focal plaques of spindle-shaped cells that expressed alpha-smooth muscle actin, and that… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 50 REFERENCES

Cataract induction in lenses cultured with transforming growth factor-beta.

  • Investigative ophthalmology & visual science
  • 1995
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

A major advance in the use of growth factors to enhance wound healing.

  • The Journal of clinical investigation
  • 1993
VIEW 8 EXCERPTS
HIGHLY INFLUENTIAL

Wound healing in the mouse lens.

  • Experimental eye research
  • 1981
VIEW 8 EXCERPTS
HIGHLY INFLUENTIAL

Experimental cataract and wound healing in mouse lens.

  • Investigative ophthalmology
  • 1973
VIEW 8 EXCERPTS
HIGHLY INFLUENTIAL