Lens morphogenesis is dependent on Pax6-mediated inhibition of the canonical Wnt/beta-catenin signaling in the lens surface ectoderm.

@article{Macho2010LensMI,
  title={Lens morphogenesis is dependent on Pax6-mediated inhibition of the canonical Wnt/beta-catenin signaling in the lens surface ectoderm.},
  author={Ondřej Machoň and Jana Kreslov{\'a} and Jana Rů{\vz}i{\vc}kov{\'a} and Tomas Vacik and Lucie Klimova and Naoko Fujimura and Jitka L{\'a}chov{\'a} and Zbyněk Kozm{\'i}k},
  journal={Genesis},
  year={2010},
  volume={48 2},
  pages={86-95}
}
Lens formation in mouse is critically dependent on proper development of the retinal neuroectoderm that is located close beneath the head surface ectoderm. Signaling from the prospective retina triggers lens-specific gene expression in the surface-ectoderm. Supression of canonical Wnt/beta-catenin signaling in the surface ectoderm is one of the prerequisites for lens development because, as we show here, ectopic Wnt activation in the retina and lens abrogates lens formation. Wnt inhibiton is… CONTINUE READING

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