Lens gap junctional coupling is modulated by connexin identity and the locus of gene expression.

@article{MartinezWittinghan2004LensGJ,
  title={Lens gap junctional coupling is modulated by connexin identity and the locus of gene expression.},
  author={Francisco J. Martinez-Wittinghan and Caterina Sellitto and Thomas W. White and Richard T. Mathias and David Paul and Daniel A. Goodenough},
  journal={Investigative ophthalmology & visual science},
  year={2004},
  volume={45 10},
  pages={3629-37}
}
PURPOSE To investigate the effects of reducing connexin (Cx) diversity in the lens when the amount of connexin protein is nearly constant. METHODS Lenses in which the Cx50 coding region was replaced by that of Cx46 (knockin [KI]), were compared with wild type (WT) and Cx50-knockout (KO) lenses. Gap junctional conductance (G(j)), and membrane conductance were evaluated by using frequency domain impedance of intact lenses. RESULTS KO of Cx50 produced small depolarized lenses with central… CONTINUE READING