Lens fibre cell differentiation - A link with apoptosis?

  title={Lens fibre cell differentiation - A link with apoptosis?},
  author={Ralf Dahm},
  journal={Ophthalmic research},
  volume={31 3},
  • Ralf Dahm
  • Published 1999 in Ophthalmic research
During the process of terminal differentiation, the fibre cells in the eye lens undergo many changes that are reminiscent of apoptotic/necrotic changes. Mitochondria, for instance, undergo permeability transition and nuclear degradation is accompanied by chromatin condensation, disintegration of the nucleolus, dissolution of the nuclear lamina, nuclear pore clustering and fragmentation of the DNA into oligonucleosomal fragments. As during apoptosis, members of the caspase family of proteases… CONTINUE READING
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