Lens development in a dominant X-linked congenital cataract of the mouse.

Xcat is a recently identified mouse mutation causing X-linked dominant congenital cataract. The mutation is of particular interest as a possible animal model for the human X-linked cataract syndrome. Using light microscopy, we examined the histological changes of mutant lenses at selected intervals between embryonic (E) day 14 and postnatal (P) day 21. At… CONTINUE READING