Lens development and crystallin gene expression : many roles for Pax6 Ale 5 Cvekl and

  title={Lens development and crystallin gene expression : many roles for Pax6 Ale 5 Cvekl and},
  author={Joram Piatigorsky},
The vertebrate eye lens has been used extensively as a model for developmental processes such as determination, embryonic induction, cellular differentiation, transdifferentiation and regeneration, with the crystallin genes being a prime example of developmentally controlled, tissue-preferred gene expression. Recent studies have shown that Pax-6, a transcription factor containing both a paired domain and homeodomain, is a key protein regulating lens determination and crystallin gene expression… CONTINUE READING
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