Lens crystallins and their microbial homologs: structure, stability, and function.

  title={Lens crystallins and their microbial homologs: structure, stability, and function.},
  author={R. C. A. Jaenicke and Christine Slingsby},
  journal={Critical reviews in biochemistry and molecular biology},
  volume={36 5},
abg-Crystallins are the major protein components in the vertebrate eye lens--a as a molecular chaperone and b and g as structural proteins. Surprisingly, the latter two share some structural characteristics with a number of microbial stress proteins. The common denominator is not only the Greek key topology of their polypeptide chains but also their high intrinsic stability, which, in certain microbial crystallin homologs, is further enhanced by high-affinity Ca2+-binding. Recent studies of… CONTINUE READING


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