Lenient versus strict rate control in patients with atrial fibrillation.

@article{Gelder2010LenientVS,
  title={Lenient versus strict rate control in patients with atrial fibrillation.},
  author={Isabelle Van Gelder and Hessel F Groenveld and Harry J. G. M. Crijns and Ype S. Tuininga and Jan G. P. Tijssen and A Marco W Alings and Hans L. Hillege and Johanna A Bergsma-Kadijk and Jan Hein Cornel and Otto Kamp and Raymond Tukkie and Hans A. Bosker and Dirk Jan van Veldhuisen and Maarten P. van den Berg},
  journal={The New England journal of medicine},
  year={2010},
  volume={362 15},
  pages={1363-73}
}
BACKGROUND Rate control is often the therapy of choice for atrial fibrillation. Guidelines recommend strict rate control, but this is not based on clinical evidence. We hypothesized that lenient rate control is not inferior to strict rate control for preventing cardiovascular morbidity and mortality in patients with permanent atrial fibrillation. METHODS We randomly assigned 614 patients with permanent atrial fibrillation to undergo a lenient rate-control strategy (resting heart rate <110… CONTINUE READING

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