Length of storage and in vitro immunomodulation induced by prestorage leukoreduced red blood cells.

  title={Length of storage and in vitro immunomodulation induced by prestorage leukoreduced red blood cells.},
  author={Oliver Karam and Marisa Tucci and Baruch Joseph Toledano and Nancy Robitaille and Jocelyne Cousineau and Louis Thibault and Jacques Lacroix and Françoise le Deist},
  volume={49 11},
BACKGROUND The relationship between length of storage of red blood cell (RBC) units and biochemical changes has been well studied, but little is known about the progression of cellular immunomodulative properties in blood recipients. This study aims to quantify in vitro T-cell activation and cytokine release by white blood cells, after incubation with supernatants from leukoreduced RBCs. STUDY DESIGN AND METHODS Whole blood cultures were incubated with supernatant from five leukoreduced RBC… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 23 extracted citations

Perioperative red blood cell transfusion in orofacial surgery

Journal of dental anesthesia and pain medicine • 2017
View 1 Excerpt

Red blood cell transfusion in surgical cancer patients: Targets, risks, mechanistic understanding and further therapeutic opportunities.

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis • 2017
View 1 Excerpt

Clinical Outcomes Associated With RBC Transfusions in Critically Ill Children: A 1-Year Prospective Study.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies • 2015

Similar Papers

Loading similar papers…