Length-independent structural similarities enrich the antibody CDR canonical class model

  title={Length-independent structural similarities enrich the antibody CDR canonical class model},
  author={Jaroslaw Nowak and Terry S Baker and Guy Georges and Sebastian Kelm and Stefan Klostermann and Jiye Shi and Sudharsan Sridharan and Charlotte M. Deane},
  pages={751 - 760}
ABSTRACT Complementarity-determining regions (CDRs) are antibody loops that make up the antigen binding site. Here, we show that all CDR types have structurally similar loops of different lengths. Based on these findings, we created length-independent canonical classes for the non-H3 CDRs. Our length variable structural clusters show strong sequence patterns suggesting either that they evolved from the same original structure or result from some form of convergence. We find that our length… 
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