Length, Protein-Protein Interactions, and Complexity

  title={Length, Protein-Protein Interactions, and Complexity},
  author={Taison Tan and Daan Frenkel and Vishal Gupta and Michael W. Deem},
The evolutionary reason for the increase in gene length from archaea to prokaryotes to eukaryotes observed in large scale genome sequencing efforts has been unclear. We propose here that the increasing complexity of protein-protein interactions has driven the selection of longer proteins, as longer proteins are more able to distinguish among a larger number of distinct interactions due to their greater average surface area. Annotated protein sequences available from the SWISS-PROT database were… CONTINUE READING
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