Lenalidomide induces degradation of IKZF1 and IKZF3

@inproceedings{Krnke2014LenalidomideID,
  title={Lenalidomide induces degradation of IKZF1 and IKZF3},
  author={Jan Kr{\"o}nke and Slater N. Hurst and Benjamin L. Ebert},
  booktitle={Oncoimmunology},
  year={2014}
}
  • Jan Krönke, Slater N. Hurst, Benjamin L. Ebert
  • Published in Oncoimmunology 2014
  • Medicine
  • Lenalidomide and its analogs, thalidomide and pomalidomide, specifically inhibit growth of mature B-cell lymphomas, including multiple myeloma, and induce interleukin-2 (IL-2) release from T cells. We recently found that this results from activation of the CRBN-CRL4 E3 ubiquitin ligase to degrade the lymphoid transcription factors IKZF1 (Ikaros) and IKZF3 (Aiolos). 

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    References

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