Lenalidomide augments actin remodeling and lowers NK-cell activation thresholds.

  title={Lenalidomide augments actin remodeling and lowers NK-cell activation thresholds.},
  author={Kathryn Lagrue and Alex Carisey and David J Morgan and Rajesh Chopra and Daniel M. Davis},
  volume={126 1},
As multiple myeloma (MM) progresses, natural killer (NK)-cell responses decline against malignant plasma cells. The immunomodulatory drug lenalidomide is widely used for treatment of MM but its influence on NK-cell biology is unclear. Here, we report that lenalidomide lowers the threshold for NK-cell activation, causing a 66% decrease in the 50% effective concentration (EC50) for activation through CD16, and a 38% decrease in EC50 for NK group 2 member D (NKG2D)-mediated activation, allowing NK… CONTINUE READING


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Proceedings of the National Academy of Sciences of the United States of America • 2014

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