Leishmanicidal activity of the alkaloid-rich fraction from Guatteria latifolia.

@article{Ferreira2017LeishmanicidalAO,
  title={Leishmanicidal activity of the alkaloid-rich fraction from Guatteria latifolia.},
  author={Christian Ferreira and Carlos L A Passos and Deivid C Soares and K{\^e}nia de P. Costa and Michelle Jakeline Cunha Rezende and Adriana Quintella Lob{\~a}o and {\^A}ngelo da Cunha Pinto and Lidilhone Hamerski and Elvira Maria Saraiva},
  journal={Experimental parasitology},
  year={2017},
  volume={172},
  pages={
          51-60
        }
}
Leishmaniasis is caused by protozoan parasites belonging to the genus Leishmania and includes cutaneous, mucocutaneous and visceral clinical forms. The drugs currently available for leishmaniasis treatment are pentavalent antimonials, amphotericin B and miltefosine, which present high toxicity, elevated cost and development of parasite resistance. The natural products constitute an important source of substances with leishmanicidal potential. Here we evaluated in vitro the anti-Leishmania… Expand
Anti-Leishmania amazonensis activity of the terpenoid fraction from Eugenia pruniformis leaves.
TLDR
The results showed the antileishmanial activity of E. pruniformis terpenoids and its potential for further studies as a source of new drugs for leishmaniasis. Expand
In vitro leishmanicidal activity of monoterpenes present in two species of Protium (Burseraceae) on Leishmania amazonensis.
TLDR
Oleoresins of Protium genus are potent against Leishmania and α-pinene, p-cymene and 1,8-cineole have anti-Leishmania properties that could be explored in synergistic assays in order to develop new drug candidates. Expand
Antileishmanial Activity, Cytotoxicity and Mechanism of Action of Clioquinol Against Leishmania infantum and Leishmania amazonensis Species
TLDR
This study demonstrates, for the first time, the antileishmanial activity of clioquinol against two relevant Leishmania species and suggests that the mitochondria of the parasites may be a possible biological target leading to parasite necrosis. Expand
Identification of Chalcone Derivatives as Inhibitors of Leishmania infantum Arginase and Promising Antileishmanial Agents
TLDR
The results presented here support the use of substituted chalcone skeletons as promising LiARG inhibitors and antileishmanial drug candidates. Expand
Alternative treatment studies for Leishmaniasis
Leishmaniasis is a vector-borne zoonotic disease that is common in the world. Because of the difficulties in the treatment and control of the disease, the disease has gained popularity amongExpand
Prospecção científica e tecnológica de Pilocarpus microphyllus e do alcaloide epiisopiloturina com ênfase na atividade antileishmania
As leishmanioses são doenças parasitárias que afetam as populações do mundo todo, principalmente as de países em desenvolvimento. A terapêutica disponível apresenta efeitos adversos graves e aExpand

References

SHOWING 1-10 OF 43 REFERENCES
Antileishmanial activity of isolated triterpenoids from Pourouma guianensis.
TLDR
The results indicate that Pourouma guianensis contains many triterpenoids and some, such as ursolic and oleanolic acids, may serve as lead compounds for new antileishmanial drugs, but chemical modifications may be necessary to avoid unselective cytotoxicity. Expand
Leishmanicidal activity and cytotoxicity of compounds from two Annonacea species cultivated in Northeastern Brazil.
TLDR
These results characterize A. squamosa and A. muricata as potential sources of leishmanicidal agents as well as evaluating the cytotoxicity of these plants against Leishmania chagasi. Expand
Oleanonic acid from Lippia lupulina (Verbenaceae) shows strong in vitro antileishmanial and antitrypanosomal activity
TLDR
The results indicate that Lippia plants and their derivatives deserve further investigation in the search for new antiprotozoal drugs, particularly for the treatment of leishmaniasis and Chagas disease. Expand
Antiprotozoal activities of Colombian plants.
TLDR
The methylene chloride extract of leaves from C. scoparioides showed a selectivity index in the same range that the one of the Glucantime control, and several of the active leishmanicidal plants are traditionally used against leish maniasis by the population of the concerned area. Expand
Leishmanicidal effects of piperine, its derivatives, and analogues on Leishmania amazonensis.
TLDR
Piperine and its phenylamide analogue are candidates for development of drugs for cutaneous leishmaniasis treatment, suggesting that they affect different target mechanisms. Expand
Trans-β-Caryophyllene: An Effective Antileishmanial Compound Found in Commercial Copaiba Oil (Copaifera spp.)
This study investigated the leishmanicidal activity against Leishmania amazonensis of four commercial oils from Copaifera spp. named as C1, C2, C3, and C4, the sesquiterpene and diterpene poolsExpand
Plants as Antileishmanial Agents: Current Scenario
TLDR
A systematic cross‐sectional study for antileishmanial activity of natural products was carried out using multiple literature databases and the records retrieved since 2000 till year 2016 were analysed and summarized in the form of comprehensive tables and graphs. Expand
Brazilian flora extracts as source of novel antileishmanial and antifungal compounds.
TLDR
These findings confirm the traditional therapeutic use of these plants in the treatment of infectious and inflammatory disorders and also offer insights into the isolation of active and novel drug prototypes, especially those used against neglected diseases as Leishmaniasis. Expand
Antileishmanial activity and trypanothione reductase effects of terpenes from the Amazonian species Croton cajucara Benth (Euphorbiaceae).
TLDR
Clerodane diterpenes from C. cajucara showed promising in vitro antileishmanial effects against L. amazonensis, specially the DCTN with no macrophage toxicity up to the assayed concentration, and a possible mechanism of action was revealed. Expand
Resveratrol Is Active against Leishmania amazonensis: In Vitro Effect of Its Association with Amphotericin B
TLDR
The anti-Leishmania effect of resveratrol and its potential synergistic association with AMB indicate that these compounds should be subjected to further studies of drug association therapy in vivo. Expand
...
1
2
3
4
5
...