Leishmanicidal activity of Echinaster (Othilia) echinophorus crude extract.

  title={Leishmanicidal activity of Echinaster (Othilia) echinophorus crude extract.},
  author={Marley Garc{\'i}a Parra and Lianet Monzote Fidalgo and Judith Mart{\'i}nez and Ana Margarita Montalvo Alvarez and Olga Vald{\'e}s Iglesias},
  journal={Revista do Instituto de Medicina Tropical de Sao Paulo},
  volume={52 2},
In this study, a methanolic extract from Echinaster (Othilia) echinophorus was evaluated for activity against Leishmania amazonensis. The extract showed activity against the promastigote and amastigote forms with IC50 values of 62.9 and 37.5 microg.mL-1 respectively. This extract showed a moderate toxicity on macrophages from BALB/c mice. A dose of 100 mg/kg/day was effective when administered during 15 days by intraperitoneal route to BALB/c mice infected experimentally. 

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