Leishmaniasis: drug resistance and natural products (review).

  title={Leishmaniasis: drug resistance and natural products (review).},
  author={Tilman Polonio and Thomas H Efferth},
  journal={International journal of molecular medicine},
  volume={22 3},
Epidemics of fatal visceral leishmaniasis caused by the intracellular protozoan Leishmania are a severe public health problem in tropical and subtropical regions of the world. One major drawback in the treatment of leishmaniasis is the emergence of resistance to current chemotherapeutics. Leishmanicidals have to be administered in low doses since commonly used drugs exhibit severe side effects, and hence drug resistance can appear rapidly. Since, to date, vaccination approaches have failed to… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 37 extracted citations


Publications referenced by this paper.
Showing 1-10 of 92 references

Antileishmanial activity of crude extract and coumarin from Calophyllum brasiliense leaves against Leishmania amazonensis

  • MA Brenzan, CV Nakamura, B PradoDiasFilho
  • Parasitol Res
  • 2007

Molecular mechanisms of antimony resistance in Leishmania

  • S Sundar, N Goyal
  • J Med Microbiol
  • 2007

Similar Papers

Loading similar papers…