Leishmania-released nucleoside diphosphate kinase prevents ATP-mediated cytolysis of macrophages.

@article{Kolli2008LeishmaniareleasedND,
  title={Leishmania-released nucleoside diphosphate kinase prevents ATP-mediated cytolysis of macrophages.},
  author={Bala K. Kolli and Jan Kostal and Olga E. Zaborina and Ananda M. Chakrabarty and K P Chang},
  journal={Molecular and biochemical parasitology},
  year={2008},
  volume={158 2},
  pages={163-75}
}
Leishmania amazonensis was found to release nucleoside diphosphate kinase (NdK)-a stable enzyme capable of decreasing extracellular ATP. The release of this enzyme from Leishmania results in its progressive accumulation extracellularly as they replicate, peaking at the stationary phase in vitro. The released NdK is immunoprecipitable and constitutes… CONTINUE READING