Leishmania promotes its own virulence by inducing expression of the host immune inhibitory ligand CD200.


Leishmania parasites infect macrophages, cells normally involved in innate defense against pathogens. Leishmania amazonensis and Leishmania major cause severe or mild disease, respectively, consistent with each parasite's ability to survive within activated macrophages. The mechanisms underlying increased virulence of L. amazonensis are mostly unknown. We… (More)
DOI: 10.1016/j.chom.2011.04.014


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