Leishmania promastigotes require lipophosphoglycan to actively modulate the fusion properties of phagosomes at an early step of phagocytosis.

@article{Dermine2000LeishmaniaPR,
  title={Leishmania promastigotes require lipophosphoglycan to actively modulate the fusion properties of phagosomes at an early step of phagocytosis.},
  author={J F Dermine and S Scianimanico and Charles Priv{\'e} and Albert Descoteaux and Michel Desjardins},
  journal={Cellular microbiology},
  year={2000},
  volume={2 2},
  pages={115-26}
}
The lipophosphoglycan (LPG) of Leishmania promastigotes plays key roles in parasite survival in both insect and mammalian hosts. Evidence suggests that LPG decreases phagosome fusion properties at the onset of infection in macrophages. The mechanisms of action of this molecule are, however, poorly understood. In the present study, we used a panoply of Leishmania mutants displaying modified LPG structures to determine more precisely how LPG modulates phagosome-endosome fusion. Using an in vivo… CONTINUE READING