Leishmania pifanoi proteoglycolipid complex P8 induces macrophage cytokine production through Toll-like receptor 4.

@article{Whitaker2008LeishmaniaPP,
  title={Leishmania pifanoi proteoglycolipid complex P8 induces macrophage cytokine production through Toll-like receptor 4.},
  author={Shanta M Whitaker and Mar{\'i}a Colmenares and Karen Goldsmith Pestana and Diane McMahon-Pratt},
  journal={Infection and immunity},
  year={2008},
  volume={76 5},
  pages={2149-56}
}
The P8 proteoglycolipid complex (P8 PGLC) is a glyconjugate expressed by Leishmania mexicana complex parasites. We previously have shown that vaccination with P8 PGLC provides protection against cutaneous leishmaniasis in susceptible BALB/c mice. However, the biological importance of this complex remains unknown. Here we show that P8 PGLC localizes to the surface of Leishmania pifanoi amastigotes and that upon exposure to macrophages, P8 PGLC binds and induces inflammatory cytokine and… CONTINUE READING