Leishmania parasites possess a platelet-activating factor acetylhydrolase important for virulence.

  title={Leishmania parasites possess a platelet-activating factor acetylhydrolase important for virulence.},
  author={Mattie C. Pawlowic and Kai Zhang},
  journal={Molecular and biochemical parasitology},
  volume={186 1},
  • Mattie C. Pawlowic, Kai Zhang
  • Published 2012
  • Biology, Medicine
  • Molecular and biochemical parasitology
  • Leishmania parasites are intracellular protozoans capable of salvaging and remodeling lipids from the host. To understand the role of lipid metabolism in Leishmania virulence, it is necessary to characterize the enzymes involved in the uptake and turnover of phospholipids. This study focuses on a putative phospholipase A2 (PLA2)/platelet-activating factor acetylhydrolase (PAF-AH) in Leishmania major. In mammals, PAF-AH is a subgroup of PLA2 catalyzing the hydrolysis/inactivation of platelet… CONTINUE READING
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