Leishmania mexicana amastigotes inhibit p38 and JNK and activate PI3K/AKT: role in the inhibition of apoptosis of dendritic cells.

@article{VzquezLpez2015LeishmaniaMA,
  title={Leishmania mexicana amastigotes inhibit p38 and JNK and activate PI3K/AKT: role in the inhibition of apoptosis of dendritic cells.},
  author={Rosalino V{\'a}zquez-L{\'o}pez and Jes{\'u}s Argueta-Donohu{\'e} and Arturo A. Wilkins-Rodr{\'i}guez and Alma Reyna Escalona-Monta{\~n}o and M Magdalena Aguirre-Garcia and Laila Guti{\'e}rrez-Kobeh},
  journal={Parasite immunology},
  year={2015},
  volume={37 11},
  pages={579-89}
}
Leishmania mexicana is the causal agent of cutaneous leishmaniasis in Mexico. Dendritic cells (DC) are one of the host cells of Leishmania parasites. Intracellular microorganisms inhibit host cell apoptosis as a strategy to ensure their survival in infected cells. We have previously shown that Leishmania mexicana promastigotes and amastigotes inhibit camptothecin-induced apoptosis of monocyte-derived dendritic cells (moDC), but the mechanisms underlying the inhibition of apoptosis of DC by… CONTINUE READING
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