Leishmania mexicana: chemistry and biochemistry of sodium stibogluconate (Pentostam).

@article{Berman1988LeishmaniaMC,
  title={Leishmania mexicana: chemistry and biochemistry of sodium stibogluconate (Pentostam).},
  author={J. Berman and M. Grogl},
  journal={Experimental parasitology},
  year={1988},
  volume={67 1},
  pages={
          96-103
        }
}
The chemical properties of the primary antileishmanial agent sodium stibogluconate (Pentostam), and the interaction of Pentostam with Leishmania mexicana amastigotes, have been investigated with the aid of [125Sb]Pentostam. The molecular weight by P2 chromatography showed [125Sb]Pentostam to be of multiple species of MW = 100-4000 Da, rather than the one species of 746 Da predicted by the commonly hypothesized structural formula. Nonradioactive Pentostam had a lower osmolarity (789 mOsm for a… Expand
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