Leishmania mexicana: binding of promastigotes to type I collagen.

  title={Leishmania mexicana: binding of promastigotes to type I collagen.},
  author={R Lira and Jos{\'e} Luis Rosales-Encina and Carlos Arg{\"u}ello},
  journal={Experimental parasitology},
  volume={85 2},
During leishmania infection, parasites are inoculated to the human host through the bite of a sandfly vector into the dermis, where they first interact with tissue components, cells and extracellular matrix molecules. Since collagen is the most abundant component of the skin matrix, we investigated whether there is a specific interaction of Leishmania mexicana promastigotes with this host component. Promastigotes were able to attach to collagen fibrils and move through the matrix of mouse skin… CONTINUE READING