Leishmania major parasites express cyclophilin isoforms with an unusual interaction with calcineurin.

@article{Rascher1998LeishmaniaMP,
  title={Leishmania major parasites express cyclophilin isoforms with an unusual interaction with calcineurin.},
  author={Christine Rascher and Andreas Pahl and Anja Pecht and Kay Brune and W Solbach and Haejeen Bang},
  journal={The Biochemical journal},
  year={1998},
  volume={334 ( Pt 3)},
  pages={659-67}
}
The immunosuppressive effects of the fungal metabolite cyclosporin A (CsA) are mediated primarily by binding to cyclophilins (Cyps). The resulting CsA-Cyp complex inhibits the Ca2+-regulated protein phosphatase calcineurin and down-regulates signal transduction events. Previously we reported that CsA is a potent inhibitor of infections transmitted by the human pathogenic protozoan parasite Leishmania major in vitro and in vivo, but does not effect the extracellular growth of L. major itself. It… CONTINUE READING

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