Leishmania major interferes with antigen presentation by infected macrophages.

  title={Leishmania major interferes with antigen presentation by infected macrophages.},
  author={Ulrich Fruth and N Solioz and Jacques A. Louis},
  journal={Journal of immunology},
  volume={150 5},
Impairment of the Ag-presenting capacity of macrophages harboring intracellular Leishmania might represent one of the several mechanisms by which these parasites can evade host-protective T cell responses. Thus, the present study was designed to investigate the ability of macrophages, parasitized with Leishmania major, to present Ag to relevant T cell hybridomas. Results show that bone marrow-derived macrophages from BALB/c mice, after infection with L. major, have a greatly reduced capacity to… CONTINUE READING
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