Leishmania major heat shock protein 70 (HSP70) is not protective in murine models of cutaneous leishmaniasis and stimulates strong humoral responses in cutaneous and visceral leishmaniasis patients.

@article{Rafati2007LeishmaniaMH,
  title={Leishmania major heat shock protein 70 (HSP70) is not protective in murine models of cutaneous leishmaniasis and stimulates strong humoral responses in cutaneous and visceral leishmaniasis patients.},
  author={Sima Rafati and Elham Gholami and Nafiseh Hassani and Fatemeh Ghaemimanesh and Yasaman Taslimi and Tahereh Taheri and Lynn Soong},
  journal={Vaccine},
  year={2007},
  volume={25 21},
  pages={4159-69}
}
Heat shock proteins (HSP) are highly conserved molecules that play important roles in protein folding, assembly of protein complexes and translocation of proteins across cellular compartments, as well as in several immunological processes. In this study, we first immunized susceptible BALB/c and resistant C57BL/6 mice with the complete open-reading frame of Leishmania HSP-70 (pcDNA-HSP70) and boosted mice with rHSP-70 (amino acid 221-604 cloned in pQE-HSP70 and referred to as rHSP70) mixed with… CONTINUE READING

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