Leishmania major ascorbate peroxidase overexpression protects cells against reactive oxygen species-mediated cardiolipin oxidation.

@article{Dolai2008LeishmaniaMA,
  title={Leishmania major ascorbate peroxidase overexpression protects cells against reactive oxygen species-mediated cardiolipin oxidation.},
  author={Subhankar Dolai and Rajesh K. Yadav and Swati Pal and Subrata Adak},
  journal={Free radical biology & medicine},
  year={2008},
  volume={45 11},
  pages={
          1520-9
        }
}
Heme peroxidases are a class of multifunctional redox-active proteins found in all organisms. We recently cloned, expressed, and characterized an ascorbate peroxidase from Leishmania major (LmAPX) that was capable of detoxifying hydrogen peroxide. Localization studies using green fluorescent protein fusions revealed that LmAPX was localized within the mitochondria by its N-terminal signal sequence. Subcellular fractionation analysis of the cell homogenate by the Percoll density-gradient method… CONTINUE READING
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