Leishmania major activates IL-1 alpha expression in macrophages through a MyD88-dependent pathway.

@article{Hawn2002LeishmaniaMA,
  title={Leishmania major activates IL-1 alpha expression in macrophages through a MyD88-dependent pathway.},
  author={Thomas Richard Hawn and Adrian O Ozinsky and David M Underhill and Frederick S Buckner and Shizuo Akira and Alan Aderem},
  journal={Microbes and infection},
  year={2002},
  volume={4 8},
  pages={763-71}
}
Leishmania species present unusual challenges to the immune system with their capacity to downregulate inflammatory responses as well as their ability to live within macrophages. Although toll-like receptor (TLR) pathways have been implicated in the recognition of several classes of pro-inflammatory microbes, it is not known if pathogens with anti-inflammatory properties activate the host response through this family of proteins. In this study, Leishmania major stimulation of cytokine promoter… CONTINUE READING

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