Leishmania major Infection in Humanized Mice Induces Systemic Infection and Provokes a Nonprotective Human Immune Response

@article{Wege2012LeishmaniaMI,
  title={Leishmania major Infection in Humanized Mice Induces Systemic Infection and Provokes a Nonprotective Human Immune Response},
  author={Anja Kathrin Wege and Christian Flori{\'a}n and W Ernst and Nicole Zimara and Ulrike Schleicher and Frank Hanses and Maximilian Schmid and Uwe Ritter},
  journal={PLoS Neglected Tropical Diseases},
  year={2012},
  volume={6}
}
Background Leishmania (L.) species are the causative agent of leishmaniasis. Due to the lack of efficient vaccine candidates, drug therapies are the only option to deal with cutaneous leishmaniasis. Unfortunately, chemotherapeutic interventions show high toxicity in addition to an increased risk of dissemination of drug-resistant parasites. An appropriate laboratory animal based model is still missing which allows testing of new drug strategies in the context of human immune cells in vivo… 
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TLDR
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