Leishmania major: interleukin-13 increases the infection-induced hyperalgesia and the levels of interleukin-1beta and interleukin-12 in rats.

@article{Haber2009LeishmaniaMI,
  title={Leishmania major: interleukin-13 increases the infection-induced hyperalgesia and the levels of interleukin-1beta and interleukin-12 in rats.},
  author={Marc Haber and Costantine F. Daher and Marc Christophe Karam and George M Baroody},
  journal={Experimental parasitology},
  year={2009},
  volume={121 3},
  pages={224-9}
}
Interleukin-13 (IL-13) is a powerful anti-inflammatory cytokine that was previously shown to be a susceptibility factor for Leishmania major (L. major) infection. In this study we report a different role for IL-13 in rats infected with L. major; rIL-13 stimulates expression of pro-inflammatory cytokines and IL-12 which is a key cytokine in protective immunity against Leishmania. Infected rats received daily injections of rIL-13 for eight consecutive days which resulted in increased pain… CONTINUE READING