Leishmania major: clathrin and adaptin complexes of an intra-cellular parasite.

@article{Denny2005LeishmaniaMC,
  title={Leishmania major: clathrin and adaptin complexes of an intra-cellular parasite.},
  author={Paul W Denny and Gareth W. Morgan and Mark C. Field and Deborah F. Smith},
  journal={Experimental parasitology},
  year={2005},
  volume={109 1},
  pages={33-7}
}
To investigate the role of clathrin-mediated trafficking during the Leishmania lifecycle, open reading frames encoding clathrin heavy chain and the beta-adaptins, major components of the adaptor complexes, have been analysed both in silico and experimentally. The Leishmania genome encodes three beta-adaptins, which arose at a time predating speciation of these divergent trypanosomatids. Unlike Trypanosoma brucei, both clathrin heavy chain and beta-adaptin1 are constitutively expressed… CONTINUE READING

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