Leishmania-infected macrophages are targets of NK cell-derived cytokines but not of NK cell cytotoxicity.

@article{Prajeeth2011LeishmaniainfectedMA,
  title={Leishmania-infected macrophages are targets of NK cell-derived cytokines but not of NK cell cytotoxicity.},
  author={Chittappen Kandiyil Prajeeth and Simone Haeberlein and Heidi Sebald and Ulrike Schleicher and Christian Bogdan},
  journal={Infection and immunity},
  year={2011},
  volume={79 7},
  pages={2699-708}
}
Natural killer (NK) cells are important components of a protective immune response against intracellular pathogens such as Leishmania parasites, which reside within myeloid cells. Previous in vivo studies in murine cutaneous or visceral leishmaniasis showed that NK cells are activated by conventional dendritic cells in a Toll-like receptor 9-, interleukin-12 (IL-12)-, and IL-18-dependent manner during the early phase of infection and help to restrict the tissue parasite burden by unknown… CONTINUE READING

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