Leishmania donovani promastigotes evade the antimicrobial activity of neutrophil extracellular traps

@inproceedings{Gabriel2010LeishmaniaDP,
  title={Leishmania donovani promastigotes evade the antimicrobial activity of neutrophil extracellular traps},
  author={Christelle Gabriel and R Mcmaster and Denis Girard and Albert Descoteaux},
  booktitle={Journal of immunology},
  year={2010}
}
Upon their recruitment to a site of infection and their subsequent activation, neutrophils release DNA and a subset of their granule content to form filamentous structures, known as neutrophil extracellular traps, which capture and kill microorganisms. In this study, we show that Leishmania promastigotes induced the rapid release of neutrophil extracellular traps from human neutrophils and were trapped by these structures. The use of Leishmania mutants defective in the biosynthesis of either… CONTINUE READING

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