Leishmania donovani polyamine biosynthetic enzyme overproducers as tools to investigate the mode of action of cytotoxic polyamine analogs.

@article{Roberts2007LeishmaniaDP,
  title={Leishmania donovani polyamine biosynthetic enzyme overproducers as tools to investigate the mode of action of cytotoxic polyamine analogs.},
  author={Sigrid C. Roberts and Yuqui Jiang and Judith E. Gasteier and Benjamin J Frydman and Laurence J. Marton and Olle Heby and Buddy Ullman},
  journal={Antimicrobial agents and chemotherapy},
  year={2007},
  volume={51 2},
  pages={438-45}
}
A number of anticancer and antiparasitic drugs are postulated to target the polyamine biosynthetic pathway and polyamine function, but the exact mode of action of these compounds is still being elucidated. To establish whether polyamine analogs specifically target enzymes of the polyamine pathway, a model was developed using strains of the protozoan parasite Leishmania donovani that overproduce each of the polyamine biosynthetic enzymes. Promastigotes overexpressing episomal constructs encoding… CONTINUE READING

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