Leishmania donovani-induced expression of suppressor of cytokine signaling 3 in human macrophages: a novel mechanism for intracellular parasite suppression of activation.

@article{Bertholet2003LeishmaniaDE,
  title={Leishmania donovani-induced expression of suppressor of cytokine signaling 3 in human macrophages: a novel mechanism for intracellular parasite suppression of activation.},
  author={Sylvie Bertholet and Harold L. Dickensheets and Faruk G Sheikh and Albert A. Gam and Raymond P Donnelly and Richard T. Kenney},
  journal={Infection and immunity},
  year={2003},
  volume={71 4},
  pages={2095-101}
}
Leishmania donovani protozoan parasites, the causative agent of visceral leishmaniasis, establish an infection partly by interfering with cytokine signaling in the host macrophages. Therefore, we investigated the expression of the suppressor of cytokine signaling (SOCS) genes in human macrophages infected with L. donovani. The expression of SOCS3 mRNA was induced transiently after exposure to live or heat-killed parasites, but not purified lipophosphoglycan, while that of other SOCS genes… CONTINUE READING

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