Leishmania donovani heat shock protein 100. Characterization and function in amastigote stage differentiation.

@article{Krobitsch1998LeishmaniaDH,
  title={Leishmania donovani heat shock protein 100. Characterization and function in amastigote stage differentiation.},
  author={Sylvia Krobitsch and S Brandau and Cornelia Hoyer and Christel Schmetz and Anja H{\"u}bel and Joachim Clos},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 11},
  pages={6488-94}
}
We report the cloning and molecular analysis of the Leishmania donovani clpB gene. The protein-coding region is highly conserved compared with its L. major homologue, while 5'- and 3'-flanking DNA sequences display considerable divergence. The encoded mRNA has an unusually long 5'-leader sequence typical for RNAs, which are translated preferentially under heat stress. The gene product, a 100-kDa heat shock protein, Hsp100, becomes abundant only during sustained heat stress, but not under common… CONTINUE READING

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