Leishmania donovani Exploits Myeloid Cell Leukemia 1 (MCL-1) Protein to Prevent Mitochondria-dependent Host Cell Apoptosis.

@article{Giri2015LeishmaniaDE,
  title={Leishmania donovani Exploits Myeloid Cell Leukemia 1 (MCL-1) Protein to Prevent Mitochondria-dependent Host Cell Apoptosis.},
  author={Jayeeta Giri and Supriya Srivastav and Moumita Basu and Shreyasi Palit and Purnima Gupta and Anindita Ukil},
  journal={The Journal of biological chemistry},
  year={2015},
  volume={291 7},
  pages={
          3496-507
        }
}
Apoptosis is one of the mechanisms used by host cells to remove unwanted intracellular organisms, and often found to be subverted by pathogens through use of host anti-apoptotic proteins. In the present study, with the help of in vitro and in vivo approaches, we documented that the macrophage anti-apoptotic protein myeloid cell leukemia 1 (MCL-1) is exploited by the intra-macrophage parasite Leishmania donovani to protect their "home" from actinomycin D-induced mitochondria-dependent apoptosis… CONTINUE READING

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