Leishmania amazonensis promastigotes in 3D Collagen I culture: an in vitro physiological environment for the study of extracellular matrix and host cell interactions

@inproceedings{Petrpolis2014LeishmaniaAP,
  title={Leishmania amazonensis promastigotes in 3D Collagen I culture: an in vitro physiological environment for the study of extracellular matrix and host cell interactions},
  author={D{\'e}bora Barreiros Petr{\'o}polis and Juliany C.F. Rodrigues and Nathan Bessa Viana and Bruno Pontes and Camila F.A. Pereira and Fernando Costa e Silva-Filho},
  booktitle={PeerJ},
  year={2014}
}
Leishmania amazonensis is the causative agent of American cutaneous leishmaniasis, an important neglected tropical disease. Once Leishmania amazonensis is inoculated into the human host, promastigotes are exposed to the extracellular matrix (ECM) of the dermis. However, little is known about the interaction between the ECM and Leishmania promastigotes. In this study we established L. amazonensis promastigote culture in a three-dimensional (3D) environment mainly composed of Collagen I (COL I… CONTINUE READING
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PeerJ, DOI 10.7717/peerj.317

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  • 2014

The role of Leishmania proteophosphoglycans in sand fly transmission and infection of the mammalian host

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